articleNucleic Acids ResearchApr 16, 2015GOLD OA

I-TASSER server: new development for protein structure and function predictions

JYJianyi YangYZYang Zhang

Washtenaw Community College · Nankai University · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

The I-TASSER server (http://zhanglab.ccmb.med.umich.edu/I-TASSER) is an online resource for automated protein structure prediction and structure-based function annotation. In I-TASSER, structural templates are first recognized from the PDB using multiple threading alignment approaches. Full-length structure models are then constructed by iterative fragment assembly simulations. The functional insights are finally derived by matching the predicted structure models with known proteins in the function databases. Although the server has been widely used for various biological and biomedical investigations, numerous comments and suggestions have been reported from the user community. In this article, we summarize…

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Topics & keywords

Topics
Keywords
  • Protein structure prediction
  • Threading (protein sequence)
  • Computer science
  • Function (biology)
  • Web server
  • Annotation
  • Protein structure database
  • Protein structure
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