articleStem CellsApr 30, 2013BRONZE OA

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

HXHongqi XinYLYi LiZLZhongwu LiuXWXinli WangXSXia Shang

Henry Ford Hospital · Oakland University

PubMed
Indexed incrossrefpubmed

Abstract

To test, in vivo, the hypothesis that exosomes from multipotent mesenchymal stromal cells (MSCs) mediate microRNA 133b (miR-133b) transfer which promotes neurological recovery from stroke, we used knockin and knockdown technologies to upregulate or downregulate the miR-133b level in MSCs (miR-133b(+) MSCs or miR-133b(-) MSCs) and their corresponding exosomes, respectively. Rats were subjected to middle cerebral artery occlusion (MCAo) and were treated with naïve MSCs, miR-133b(+) MSCs, or miR-133b(-) MSC at 1 day after MCAo. Compared with controls, rats receiving naïve MSC treatment significantly improved functional recovery and exhibited increased axonal plasticity and neurite remodeling in the ischemic…

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Topics & keywords

Topics
Keywords
  • Mesenchymal stem cell
  • Biology
  • Microvesicles
  • Gene knockdown
  • Cell biology
  • Downregulation and upregulation
  • Exosome
  • Neurotrophic factors
UN Sustainable Development Goals
  • Good health and well-being
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