articleProceedings of the National Academy of SciencesJul 25, 2009GREEN OA

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

MBMathew Blurton‐JonesMKMasashi KitazawaHMHilda Martínez‐CoriaNANicholas A. CastelloFMFranz-Josef Müller

University of California, Irvine · Scripps Research Institute · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Neural stem cell (NSC) transplantation represents an unexplored approach for treating neurodegenerative disorders associated with cognitive decline such as Alzheimer disease (AD). Here, we used aged triple transgenic mice (3xTg-AD) that express pathogenic forms of amyloid precursor protein, presenilin, and tau to investigate the effect of neural stem cell transplantation on AD-related neuropathology and cognitive dysfunction. Interestingly, despite widespread and established Ass plaque and neurofibrillary tangle pathology, hippocampal neural stem cell transplantation rescues the spatial learning and memory deficits in aged 3xTg-AD mice. Remarkably, cognitive function is improved without altering Ass or tau…

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866
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Topics & keywords

Topics
Keywords
  • Neuroscience
  • Neural stem cell
  • Transplantation
  • Neuropathology
  • Neurotrophic factors
  • Brain-derived neurotrophic factor
  • Hippocampal formation
  • Presenilin
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