T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
Harvard University · Whitehead Institute for Biomedical Research · +1 more institution
Abstract
Acrp30/adiponectin is reduced in the serum of obese and diabetic individuals, and the genetic locus of adiponectin is linked to the metabolic syndrome. Recombinant adiponectin, administered to diet-induced obese mice, induced weight loss and improved insulin sensitivity. In muscle and liver, adiponectin stimulates AMP-activated protein kinase activation and fatty acid oxidation. To expression-clone molecules capable of binding adiponectin, we transduced a C2C12 myoblast cDNA retroviral expression library into Ba/F3 cells and panned infected cells on recombinant adiponectin linked to magnetic beads. We identified T-cadherin as a receptor for the hexameric and high-molecular-weight species of adiponectin but not…
Citation impact
- FWCI
- 21.96
- Percentile
- 100%
- References
- 39
Authors
6- CHChristopher Hug
Harvard University, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
- JWJin Wang
Harvard University, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
- NSNaina Shehzeen Ahmad
Harvard University, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
- JSJonathan S. Bogan
Harvard University, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
- TTTsu‐Shuen Tsao
Harvard University, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
Topics & keywords
- Adiponectin
- Adiponectin receptor 1
- Biology
- Cell biology
- Receptor
- Internal medicine
- Endocrinology
- Biochemistry