BNP-Guided vs Symptom-Guided Heart Failure Therapy

Pfisterer, Matthias; Buser, Peter; Rickli, Hans; Gutmann, Marc; Erné, Paul; Rickenbacher, Peter; Vuillomenet, A.G.; Jeker, Urs; Dubach, Paul; Beer, Jürg H.; Yoon, Se‐Il; Suter, Thomas; Osterhues, Hans H.; Schieber, M.; Hilti, P; Schindler, Ruth; Rocca, Hans‐Peter Brunner‐La; Investigators, for the TIME-CHF

doi:10.1001/jama.2009.2

articleJAMAJan 27, 2009Closed access

BNP-Guided vs Symptom-Guided Heart Failure Therapy

MPMatthias Pfisterer PBPeter Buser HRHans Rickli MGMarc Gutmann PEPaul Erné

University Hospital of Basel

PubMed

Indexed incrossrefpubmed

Abstract

CONTEXT: It is uncertain whether intensified heart failure therapy guided by N-terminal brain natriuretic peptide (BNP) is superior to symptom-guided therapy. OBJECTIVE: To compare 18-month outcomes of N-terminal BNP-guided vs symptom-guided heart failure therapy. DESIGN, SETTING, AND PATIENTS: Randomized controlled multicenter Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) of 499 patients aged 60 years or older with systolic heart failure (ejection fraction

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642

total citations

FWCI: 42.11
Percentile: 100%
References: 32

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Authors

18

Topics & keywords

Topics

Keywords

Medicine
Heart failure
Ejection fraction
Hazard ratio
Internal medicine
Randomized controlled trial
Quality of life (healthcare)
Cardiology

UN Sustainable Development Goals

Good health and well-being

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