articleArchives of NeurologySep 1, 2002Closed access

β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease

HFHiroaki Fukumoto

Massachusetts General Hospital

PubMed
Indexed incrossrefpubmed

Abstract

Objective

To test the hypothesis that BACE protein and activity are increased in regions of the brain that develop amyloid plaques in AD.

Methods

We developed an antibody capture system to measure BACE protein level and BACE-specific beta-secretase activity in frontal, temporal, and cerebellar brain homogenates from 61 brains with AD and 33 control brains.

Citation impact

708
total citations
FWCI
10.53
Percentile
100%
References
63
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • Neocortex
  • Amyloid precursor protein
  • Chemistry
  • Alzheimer's disease
  • Cerebellar cortex
  • Temporal cortex
  • Neuroscience
  • Biochemistry
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