Macrophage diversity in renal injury and repair
Monash University · University of Groningen · +1 more institution
Abstract
Monocyte-derived macrophages can determine the outcome of the immune response and whether this response contributes to tissue repair or mediates tissue destruction. In addition to their important role in immune-mediated renal disease and host defense, macrophages play a fundamental role in tissue remodeling during embryonic development, acquired kidney disease, and renal allograft responses. This review summarizes macrophage phenotype and function in the orchestration of kidney repair and replacement of specialized renal cells following injury. Recent advances in our understanding of macrophage heterogeneity in response to their microenvironment raise new and exciting therapeutic possibilities to attenuate or…
Citation impact
- FWCI
- 13.78
- Percentile
- 100%
- References
- 132
Authors
3Topics & keywords
- Macrophage
- Fibrosis
- Immune system
- Kidney
- Context (archaeology)
- Immunology
- Disease
- Biology
- Good health and well-being