Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent
National Institutes of Health · National Human Genome Research Institute · +4 more institutions
Abstract
Idiopathic pulmonary fibrosis (IPF) is a destructive inflammatory disease with limited therapeutic options. To better understand the inflammatory responses that precede and concur with collagen deposition, we used three models of pulmonary fibrosis and identify a critical mechanistic role for IL-17A. After exposure to bleomycin (BLM), but not Schistosoma mansoni eggs, IL-17A produced by CD4(+) and gammadelta(+) T cells induced significant neutrophilia and pulmonary fibrosis. Studies conducted with C57BL/6 il17a(-/-) mice confirmed an essential role for IL-17A. Mechanistically, using ifngamma(-/-), il10(-/-), il10(-/-)il12p40(-/-), and il10(-/-)il17a(-/-) mice and TGF-beta blockade, we demonstrate that…
Citation impact
- FWCI
- 37.89
- Percentile
- 100%
- References
- 86
Authors
7- MSMark S. WilsonCorresponding
National Institutes of Health, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases
- SKSatish K. Madala
National Institutes of Health, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases
- TRThirumalai R. Ramalingam
National Institutes of Health, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases
- BRBernadette R. Gochuico
National Institutes of Health, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases
- IOIván O. Rosas
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Bleomycin
- Interleukin 17
- Pulmonary fibrosis
- Idiopathic pulmonary fibrosis
- Fibrosis
- Immunology
- Neutrophilia
- Interleukin 10
- Good health and well-being