reviewPLoS ONEMar 26, 2015GOLD OA

Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans

JEJennifer E. HuffmanEAEva AlbrechtATAlexander TeumerMMMassimo ManginoKKKaren Kapur

Institute of Genetics and Cancer · Medical Research Council · +56 more institutions

PubMed
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Abstract

We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed…

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Topics & keywords

Topics
Keywords
  • Genome-wide association study
  • Overweight
  • Body mass index
  • Locus (genetics)
  • Obesity
  • Genetics
  • Internal medicine
  • Biology
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