BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression
Dana-Farber Cancer Institute · Harvard University · +2 more institutions
Abstract
BM mesenchymal stromal cells (BM-MSCs) support multiple myeloma (MM) cell growth, but little is known about the putative mechanisms by which the BM microenvironment plays an oncogenic role in this disease. Cell-cell communication is mediated by exosomes. In this study, we showed that MM BM-MSCs release exosomes that are transferred to MM cells, thereby resulting in modulation of tumor growth in vivo. Exosomal microRNA (miR) content differed between MM and normal BM-MSCs, with a lower content of the tumor suppressor miR-15a. In addition, MM BM-MSC-derived exosomes had higher levels of oncogenic proteins, cytokines, and adhesion molecules compared with exosomes from the cells of origin. Importantly, whereas MM…
Citation impact
- FWCI
- 33.05
- Percentile
- 100%
- References
- 58
Authors
13- AMAldo M. RoccaroCorresponding
- ASAntonio Sacco
Dana-Farber Cancer Institute, Harvard University, Harvard University Press
- PMPatricia Maiso
Harvard University Press, Harvard University, Dana-Farber Cancer Institute
- AKAbdel Kareem Azab
Dana-Farber Cancer Institute, Harvard University
- YTYu-Tzu Tai
Harvard University, Dana-Farber Cancer Institute, Harvard University Press
Topics & keywords
- Microvesicles
- Mesenchymal stem cell
- Exosome
- Stromal cell
- Cancer research
- In vivo
- Cell biology
- Cell