Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
BC Cancer Agency · University of British Columbia · +3 more institutions
Abstract
Somatic missense mutations can initiate tumorogenesis and, conversely, anti-tumor cytotoxic T cell (CTL) responses. Tumor genome analysis has revealed extreme heterogeneity among tumor missense mutation profiles, but their relevance to tumor immunology and patient outcomes has awaited comprehensive evaluation. Here, for 515 patients from six tumor sites, we used RNA-seq data from The Cancer Genome Atlas to identify mutations that are predicted to be immunogenic in that they yielded mutational epitopes presented by the MHC proteins encoded by each patient's autologous HLA-A alleles. Mutational epitopes were associated with increased patient survival. Moreover, the corresponding tumors had higher CTL content,…
Citation impact
- FWCI
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- References
- 69
Authors
7- SDScott D. BrownCorresponding
BC Cancer Agency, University of British Columbia, Canada's Michael Smith Genome Sciences Centre
- RMRobin M. Warren
BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre
- EAEwan A. Gibb
BC Cancer Agency, University of British Columbia, Canada's Michael Smith Genome Sciences Centre
- SDSpencer D. Martin
BC Cancer Agency, University of British Columbia, Canada's Michael Smith Genome Sciences Centre
- JJJohn J. Spinelli
BC Cancer Agency, University of British Columbia
Topics & keywords
- Biology
- CTL*
- Missense mutation
- Epitope
- Major histocompatibility complex
- Cytotoxic T cell
- Human leukocyte antigen
- Genome
- Good health and well-being