reviewCold Spring Harbor Perspectives in BiologyNov 20, 2012BRONZE OA

The  -Catenin Destruction Complex

JLJennifer L. StamosWIWilliam I. Weis

Stanford University

PubMed
Indexed incrossrefpubmed

Abstract

The Wnt/β-catenin pathway is highly regulated to insure the correct temporal and spatial activation of its target genes. In the absence of a Wnt stimulus, the transcriptional coactivator β-catenin is degraded by a multiprotein "destruction complex" that includes the tumor suppressors Axin and adenomatous polyposis coli (APC), the Ser/Thr kinases GSK-3 and CK1, protein phosphatase 2A (PP2A), and the E3-ubiquitin ligase β-TrCP. The complex generates a β-TrCP recognition site by phosphorylation of a conserved Ser/Thr-rich sequence near the β-catenin amino terminus, a process that requires scaffolding of the kinases and β-catenin by Axin. Ubiquitinated β-catenin is degraded by the proteasome. The molecular…

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Topics & keywords

Topics
Keywords
  • Biology
  • Wnt signaling pathway
  • Ubiquitin ligase
  • Adenomatous polyposis coli
  • Protein phosphatase 2
  • Ubiquitin
  • Casein kinase 1
  • Phosphorylation
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