B-Type Natriuretic Peptide and Clinical Judgment in Emergency Diagnosis of Heart Failure
Hartford Hospital · University of Kentucky · +4 more institutions
Abstract
BACKGROUND: We sought to determine the degree to which B-type natriuretic peptide (BNP) adds to clinical judgment in the diagnosis of congestive heart failure (CHF). METHODS AND RESULTS: The Breathing Not Properly Multinational Study was a prospective diagnostic test evaluation study conducted in 7 centers. Of 1586 participants who presented with acute dyspnea, 1538 (97%) had clinical certainty of CHF determined by the attending physician in the emergency department. Participants underwent routine care and had BNP measured in a blinded fashion. The reference standard for CHF was adjudicated by 2 independent cardiologists, also blinded to BNP results. The final diagnosis was CHF in 722 (47%) participants. At an…
Citation impact
- FWCI
- 38.53
- Percentile
- 100%
- References
- 31
Authors
19- PAPeter A. McCulloughCorresponding
Hartford Hospital, University of Kentucky, Henry Ford Hospital, Hôpital Bichat-Claude-Bernard, University of Pennsylvania, University of Cincinnati Medical Center
- RMRichard M. Nowak
Hartford Hospital, University of Kentucky, Henry Ford Hospital, Hôpital Bichat-Claude-Bernard, University of Pennsylvania, University of Cincinnati Medical Center
- JMJames McCord
Hartford Hospital, University of Kentucky, Henry Ford Hospital, Hôpital Bichat-Claude-Bernard, University of Pennsylvania, University of Cincinnati Medical Center
- JEJudd E. Hollander
Hartford Hospital, University of Kentucky, Henry Ford Hospital, Hôpital Bichat-Claude-Bernard, University of Pennsylvania, University of Cincinnati Medical Center
- HCHoward C. Herrmann
Hartford Hospital, University of Kentucky, Henry Ford Hospital, Hôpital Bichat-Claude-Bernard, University of Pennsylvania, University of Cincinnati Medical Center
Topics & keywords
- Medicine
- Heart failure
- Natriuretic peptide
- Cutoff
- Internal medicine
- Emergency department
- Receiver operating characteristic
- Cardiology
- Good health and well-being