Comprehensive molecular portraits of human breast tumours

We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays. Our ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers; however, there were numerous subtype-associated and novel gene mutations including the enrichment of specific mutations in GATA3,…

• UD
  U.S. Department of Defense
• BC
  Breast Cancer Research Foundation

  Award: P50CA116201
• HM
  Henry M. Jackson Foundation
• NI
  National Institutes of Health

  Awards: U24CA143835, U24CA143848, U24CA143845, U54HG003079, U24CA143882, U24CA143866, U24CA143867, U24CA144025, P50CA116201, U24CA143858, U24CA143799, U24CA143840, P50CA58223, U24CA143883