Brain homogenates from human tauopathies induce tau inclusions in mouse brain

Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer's disease, tangle-only dementia, Pick disease, argyrophilic grain disease (AGD), progressive supranuclear palsy, and corticobasal degeneration. In Alzheimer's disease and AGD, it has been shown that filamentous tau appears to spread in a stereotypic manner as the disease progresses. We previously demonstrated that the injection of brain extracts from human mutant P301S tau-expressing transgenic mice into the brains of mice transgenic for wild-type human tau (line ALZ17) resulted in the assembly of wild-type human tau into filaments and the spreading of tau inclusions from…

• NS
  National Science Foundation

  Award: P30 AG010133
• VS
  Velux Stiftung
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Award: 32323B_123812
• JB
  Japanese Brain Bank Network for Neuroscience Research
• I
  Ipsen
• MR
  Medical Research Council

  Award: U105184291