Abstract
Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Global changes in the epigenetic landscape are a hallmark of cancer. The initiation and progression of cancer, traditionally seen as a genetic disease, is now realized to involve epigenetic abnormalities along with genetic alterations. Recent advancements in the rapidly evolving field of cancer epigenetics have shown extensive reprogramming of every component of the epigenetic machinery in cancer including DNA methylation, histone modifications, nucleosome positioning and…
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Authors
3Topics & keywords
Topics
Keywords
- Epigenetics
- Reprogramming
- Biology
- Epigenetic regulation of neurogenesis
- microRNA
- Epigenetic therapy
- DNA methylation
- Cancer
UN Sustainable Development Goals
- Good health and well-being
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