CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity
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Abstract
Lineage differentiation and the formation of heterogeneous mature subsets are crucial for immune cells to maintain a breadth of responsiveness to pathogens while controlling reactivity to self. In this study, we report that CD27 is a key marker of the NK cell lineage, dissecting the mature Mac-1high NK cell pool into two functionally distinct subsets. The CD27low NK cell subset possesses a higher threshold to stimulation and appears to be tightly regulated by the expression of NK cell inhibitory receptors. Comparatively, the CD27high NK cell subset displays a greater effector function, exhibits a distinct tissue distribution and responsiveness to chemokines, and interacts productively with dendritic cells.…
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2Topics & keywords
Topics
Keywords
- Biology
- Cell biology
- Lineage (genetic)
- Effector
- Chemokine receptor
- Immune system
- Phenotype
- Cell
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