Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents
Hôpital Marie Lannelongue · Inserm · +8 more institutions
Abstract
In contrast to the accepted general assumption that polyethylene glycol (PEG) is non-immunogenic and non-antigenic, animal studies clearly showed that uricase, ovalbumin and some other PEGylated agents can elicit antibody formation against PEG (anti-PEG). In humans, anti-PEG may limit therapeutic efficacy and/or reduce tolerance of PEG-asparaginase (PEG-ASNase) in patients with acute lymphoblastic leukemia and of pegloticase in patients with chronic gout, but did not impair hyposensitization of allergic patients with mPEG-modified ragweed extract or honeybee venom or the response to PEG-IFN in patients with hepatitis C. Of major importance is the recent finding of a 22 - 25% occurrence of anti-PEG in healthy…
Citation impact
- FWCI
- 13.55
- Percentile
- 100%
- References
- 32
Authors
5- RPRicardo P. GarayCorresponding
Hôpital Marie Lannelongue, Inserm
- RERaafat El-Gewely
UiT The Arctic University of Norway
- JKJonathan K. Armstrong
UCLA Medical Center, University of California, Los Angeles
- GGGeorge Garratty
American Red Cross
- PRPascal Richette
Assistance Publique – Hôpitaux de Paris, Hôpital Lariboisière, Université Paris Cité, Délégation Paris 7
Topics & keywords
- PEG ratio
- PEGylation
- Polyethylene glycol
- Medicine
- Immunogenicity
- Pharmacology
- Antigenicity
- Antibody