Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers
Kyushu University · The University of Tokyo · +1 more institution
Abstract
The functional impact of recently discovered long noncoding RNAs (ncRNAs) in human cancer remains to be clarified. One long ncRNA which has attracted attention is the Hox transcript antisense intergenic RNA termed HOTAIR, a long ncRNA expressed from the developmental HOXC locus located on chromosome 12q13.13. In cooperation with Polycomb complex PRC2, the HOTAIR long ncRNA is reported to reprogram chromatin organization and promote breast cancer metastasis. In this study, we examined the status and function of HOTAIR in patients with stage IV colorectal cancer (CRC) who have liver metastases and a poor prognosis. HOTAIR expression levels were higher in cancerous tissues than in corresponding noncancerous…
Citation impact
- FWCI
- 28.75
- Percentile
- 100%
- References
- 20
Authors
12- RKRyunosuke KogoCorresponding
Kyushu University, The University of Tokyo, The University of Osaka
- TSTeppei Shimamura
Kyushu University, The University of Tokyo, The University of Osaka
- KMKoshi Mimori
Kyushu University, The University of Tokyo, The University of Osaka
- KKKohichi Kawahara
Kyushu University, The University of Tokyo, The University of Osaka
- SISeiya Imoto
Kyushu University, The University of Tokyo, The University of Osaka
Topics & keywords
- HOTAIR
- PRC2
- Hox gene
- Biology
- Long non-coding RNA
- Non-coding RNA
- Cancer research
- Polycomb-group proteins
- No poverty