articleAnnals of the Rheumatic DiseasesMar 19, 2009HYBRID OA

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

GJGraeme JonesASAnthony SebbaJGJianhui GuMBMitchell B. LowensteinACAndrea Calvo

University of Tasmania · Sun Yat-sen University · +8 more institutions

PubMed
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Abstract

Background

The anti-interleukin (IL) 6 receptor antibody tocilizumab inhibits signalling of IL6, a key cytokine in rheumatoid arthritis (RA) pathogenesis.

Objective

To evaluate through the AMBITION study the efficacy and safety of tocilizumab monotherapy versus methotrexate in patients with active RA for whom previous treatment with methotrexate/biological agents had not failed.

Citation impact

806
total citations
FWCI
39.96
Percentile
100%
References
44
Citations per year

Authors

11

Topics & keywords

Topics
Keywords
  • Tocilizumab
  • Medicine
  • Rheumatoid arthritis
  • Methotrexate
  • Internal medicine
  • Neutropenia
  • Rheumatology
  • Placebo
UN Sustainable Development Goals
  • Good health and well-being
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Funding