Albuminuria, a Therapeutic Target for Cardiovascular Protection in Type 2 Diabetic Patients With Nephropathy
Brigham and Women's Hospital · University Medical Center Groningen · +5 more institutions
Abstract
BACKGROUND: Albuminuria is an established risk marker for both cardiovascular and renal outcomes. Albuminuria can be reduced with drugs that block the renin-angiotensin system (RAS). We questioned whether the short-term drug-induced change in albuminuria would predict the long-term cardioprotective efficacy of RAS intervention. METHODS AND RESULTS: We analyzed data from Reduction in Endpoints in Non-insulin dependent diabetes mellitus with the Angiotensin II Antagonist Losartan (RENAAL), a double-blind, randomized trial in 1513 type 2 diabetic patients with nephropathy, focusing on the relationship between the prespecified cardiovascular end point (composite) or hospitalization for heart failure and baseline…
Citation impact
- FWCI
- 26.41
- Percentile
- 100%
- References
- 34
Authors
10- DDDick de ZeeuwCorresponding
Brigham and Women's Hospital, University Medical Center Groningen, Steno Diabetes Centers, Baker Heart and Diabetes Institute, Mario Negri Institute for Pharmacological Research, Aarhus University, The University of Texas Medical Branch at Galveston
- GRGiuseppe Remuzzi
Brigham and Women's Hospital, University Medical Center Groningen, Steno Diabetes Centers, Baker Heart and Diabetes Institute, Mario Negri Institute for Pharmacological Research, Aarhus University, The University of Texas Medical Branch at Galveston
- HPHans‐Henrik Parving
Brigham and Women's Hospital, University Medical Center Groningen, Steno Diabetes Centers, Baker Heart and Diabetes Institute, Mario Negri Institute for Pharmacological Research, Aarhus University, The University of Texas Medical Branch at Galveston
- WFWilliam F. Keane
Brigham and Women's Hospital, University Medical Center Groningen, Steno Diabetes Centers, Baker Heart and Diabetes Institute, Mario Negri Institute for Pharmacological Research, Aarhus University, The University of Texas Medical Branch at Galveston
- ZZZhongxin Zhang
Brigham and Women's Hospital, University Medical Center Groningen, Steno Diabetes Centers, Baker Heart and Diabetes Institute, Mario Negri Institute for Pharmacological Research, Aarhus University, The University of Texas Medical Branch at Galveston
Topics & keywords
- Albuminuria
- Medicine
- Internal medicine
- Diabetic nephropathy
- Cardiology
- Surrogate endpoint
- Diabetes mellitus
- Type 2 diabetes
- Good health and well-being