Identification of Virus-Encoded MicroRNAs
Memorial Sloan Kettering Cancer Center · University of Basel · +5 more institutions
Abstract
RNA silencing processes are guided by small RNAs that are derived from double-stranded RNA. To probe for function of RNA silencing during infection of human cells by a DNA virus, we recorded the small RNA profile of cells infected by Epstein-Barr virus (EBV). We show that EBV expresses several microRNA (miRNA) genes. Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for degradation or by repressing translation, we identified viral regulators of host and/or viral gene expression.
Citation impact
- FWCI
- 116.24
- Percentile
- 100%
- References
- 13
Authors
11- SPSébastien PfefferCorresponding
Memorial Sloan Kettering Cancer Center, University of Basel, Universitätsklinikum des Saarlandes, Institute of Medical Microbiology and Hygiene, New York Genome Center, Columbia University, Rockefeller University
- MZMihaela Zavolan
Memorial Sloan Kettering Cancer Center, University of Basel, Universitätsklinikum des Saarlandes, Institute of Medical Microbiology and Hygiene, New York Genome Center, Columbia University, Rockefeller University
- FAFriedrich A. Grässer
Memorial Sloan Kettering Cancer Center, University of Basel, Universitätsklinikum des Saarlandes, Institute of Medical Microbiology and Hygiene, New York Genome Center, Columbia University, Rockefeller University
- MCMinchen Chien
Memorial Sloan Kettering Cancer Center, University of Basel, Universitätsklinikum des Saarlandes, Institute of Medical Microbiology and Hygiene, New York Genome Center, Columbia University, Rockefeller University
- JJJames J. Russo
Memorial Sloan Kettering Cancer Center, University of Basel, Universitätsklinikum des Saarlandes, Institute of Medical Microbiology and Hygiene, New York Genome Center, Columbia University, Rockefeller University
Topics & keywords
- Gene silencing
- microRNA
- RNA silencing
- RNA-induced silencing complex
- RNA
- Biology
- Trans-acting siRNA
- DNA-directed RNA interference