Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK)
National Cancer Institute · Institut für Medizinische Biometrie, Informatik und Epidemiologie · +3 more institutions
Abstract
Despite years of research and hundreds of reports on tumor markers in oncology, the number of markers that have emerged as clinically useful is pitifully small. Often, initially reported studies of a marker show great promise, but subsequent studies on the same or related markers yield inconsistent conclusions or stand in direct contradiction to the promising results. It is imperative that we attempt to understand the reasons that multiple studies of the same marker lead to differing conclusions. A variety of methodologic problems have been cited to explain these discrepancies. Unfortunately, many tumor marker studies have not been reported in a rigorous fashion, and published articles often lack sufficient…
Citation impact
- FWCI
- 38.74
- Percentile
- 100%
- References
- 46
Authors
6- LMLisa M. McShaneCorresponding
National Cancer Institute, Institut für Medizinische Biometrie, Informatik und Epidemiologie, Ospedale Civile di Venezia, Cancer Research UK
- DGDouglas G. Altman
National Cancer Institute, Ospedale Civile di Venezia, National Cancer Institute, Cancer Research UK, Institut für Medizinische Biometrie, Informatik und Epidemiologie
- WSWilli Sauerbrei
Cancer Research UK, National Cancer Institute, Institut für Medizinische Biometrie, Informatik und Epidemiologie, National Cancer Institute, Ospedale Civile di Venezia
- SESheila E. Taube
Institut für Medizinische Biometrie, Informatik und Epidemiologie, National Cancer Institute, National Cancer Institute, Cancer Research UK, Ospedale Civile di Venezia
- MGMassimo Gion
Ospedale Civile di Venezia, National Cancer Institute, National Cancer Institute, Institut für Medizinische Biometrie, Informatik und Epidemiologie, Cancer Research UK
Topics & keywords
- Generalizability theory
- Context (archaeology)
- Medicine
- Consolidated Standards of Reporting Trials
- Variety (cybernetics)
- Tumor marker
- Statement (logic)
- Cancer