Neuropathological Alterations in Alzheimer Disease
MaineGeneral Medical Center · Harvard University · +2 more institutions
Abstract
The neuropathological hallmarks of Alzheimer disease (AD) include "positive" lesions such as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial responses, and "negative" lesions such as neuronal and synaptic loss. Despite their inherently cross-sectional nature, postmortem studies have enabled the staging of the progression of both amyloid and tangle pathologies, and, consequently, the development of diagnostic criteria that are now used worldwide. In addition, clinicopathological correlation studies have been crucial to generate hypotheses about the pathophysiology of the disease, by establishing that there is a continuum between "normal" aging and AD dementia, and that the…
Citation impact
- FWCI
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- Percentile
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- References
- 253
Authors
4- ASAlberto Serrano‐PozoCorresponding
MaineGeneral Medical Center, Harvard University, Massachusetts General Hospital
- MPMatthew P. Frosch
Massachusetts General Hospital, MaineGeneral Medical Center, Harvard University
- EMEliezer Masliah
University of California, San Diego
- BTB. T. Hyman
MaineGeneral Medical Center, Massachusetts General Hospital, Harvard University
Topics & keywords
- Neuropathology
- General hospital
- Medical school
- Gerontology
- Medicine
- Neuroscience
- Disease
- Psychology