articlePolymer ChemistryJan 1, 2011Closed access

FDA-approved poly(ethylene glycol)–protein conjugate drugs

SNSteevens N. S. AlconcelABA. BaasHDHeather D. Maynard

California NanoSystems Institute · Ronald Reagan UCLA Medical Center

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Abstract

PEGylation or covalent attachment of poly(ethylene glycol) improves the pharmacokinetic properties of protein drugs. In vivo circulation lifetimes are increased and dosages are decreased, resulting in improved patient quality of life. PEG may be attached to proteins using a variety of different chemical reactions. This review discusses currently available FDA-approved PEGylated protein drugs, their intended use and target, and the PEG attachment chemistry utilized.

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646
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Authors

3

Topics & keywords

Topics
Keywords
  • PEGylation
  • Ethylene glycol
  • PEG ratio
  • Conjugate
  • Covalent bond
  • Chemistry
  • In vivo
  • Combinatorial chemistry
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