Anti-Mullerian Hormone Inhibits Initiation of Primordial Follicle Growth in the Mouse Ovary

Recruitment of primordial follicles is essential for female fertility;\n however, the exact mechanisms regulating this process are largely unknown.\n Earlier studies using anti-Mullerian hormone (AMH)-deficient mice\n suggested that AMH is involved in the regulation of primordial follicle\n recruitment. We tested this hypothesis in a neonatal ovary culture system,\n in which ovaries from 2-d-old C57Bl/6J mice were cultured for 2 or 4 d in\n the absence or presence of AMH. Ovaries from 2-d-old mice contain multiple\n primordial follicles, some naked oocytes, and no follicles at later stages\n of development. We observed that in the cultured ovaries, either\n nontreated or AMH-treated, follicular development…

• EU
  Erasmus Universiteit Rotterdam
• FO
  Faculty of Medicine and Health, University of Sydney