Murine Leukemia Induced by Retroviral Gene Marking

Li, Zhixiong; Düllmann, J.; Schiedlmeier, Bernd; Schmidt, Manfred; Kalle, Christof von; Meyer, Johann; Förster, M.; Stocking, Carol; Wahlers, Anke; Frank, Oliver; Ostertag, Wolfram; Kühlcke, Klaus; Eckert, Hans‐Georg; Fehse, Boris; Baum, Christopher

doi:10.1126/science.1068893

articleScienceApr 19, 2002Closed access

Murine Leukemia Induced by Retroviral Gene Marking

ZLZhixiong Li JDJ. Düllmann BSBernd Schiedlmeier MSManfred Schmidt CVChristof von Kalle

Leibniz Institute of Virology (LIV) · Medizinische Hochschule Hannover

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Abstract

Somatic gene transfer is a promising therapeutic strategy, but it may also evoke new types of side effects related to genetic damage or transgene activity. Retroviral vectors, the best tool currently available for stable genetic modification, integrate at random positions in the cellular genome. The

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Topics & keywords

Topics

Keywords

Leukemia
Gene
Biology
Murine leukemia virus
Virology
Computational biology
Genetics

UN Sustainable Development Goals

Good health and well-being

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