articleProceedings of the National Academy of SciencesAug 15, 2007GREEN OA

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

DNDaniel N. FrankALAllison L. St. AmandRARobert A. FeldmanECEdgar C. BoedekerNHNoam Harpaz

University of Colorado Boulder · Menlo School · +2 more institutions

PubMed
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Abstract

The two primary human inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), are idiopathic relapsing disorders characterized by chronic inflammation of the intestinal tract. Although several lines of reasoning suggest that gastrointestinal (GI) microbes influence inflammatory bowel disease (IBD) pathogenesis, the types of microbes involved have not been adequately described. Here we report the results of a culture-independent rRNA sequence analysis of GI tissue samples obtained from CD and UC patients, as well as non-IBD controls. Specimens were obtained through surgery from a variety of intestinal sites and included both pathologically normal and abnormal states. Our results provide…

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Topics & keywords

Topics
Keywords
  • Ulcerative colitis
  • Inflammatory bowel disease
  • Firmicutes
  • Pathogenesis
  • Bacteroidetes
  • Biology
  • NOD2
  • Gastrointestinal tract
UN Sustainable Development Goals
  • Good health and well-being
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