Isolation and Characterization of Multipotent Progenitor Cells from the Bowman’s Capsule of Adult Human Kidneys
University of Foggia · High Institute for Education and Research in Transfusion Medicine · +1 more institution
Abstract
Regenerative medicine represents a critical clinical goal for patients with ESRD, but the identification of renal adult multipotent progenitor cells has remained elusive. It is demonstrated that in human adult kidneys, a subset of parietal epithelial cells (PEC) in the Bowman's capsule exhibit coexpression of the stem cell markers CD24 and CD133 and of the stem cell-specific transcription factors Oct-4 and BmI-1, in the absence of lineage-specific markers. This CD24+CD133+ PEC population, which could be purified from cultured capsulated glomeruli, revealed self-renewal potential and a high cloning efficiency. Under appropriate culture conditions, individual clones of CD24+CD133+ PEC could be induced to…
Citation impact
- FWCI
- 13.77
- Percentile
- 100%
- References
- 51
Authors
19- CSCostanza SagrinatiCorresponding
- GSGiuseppe Stefano Netti
University of Foggia
- BMBenedetta MazzinghiCorresponding
High Institute for Education and Research in Transfusion Medicine
- ELElena LazzeriCorresponding
High Institute for Education and Research in Transfusion Medicine
- FLFrancesco LiottaCorresponding
High Institute for Education and Research in Transfusion Medicine
Topics & keywords
- Progenitor cell
- Multipotent Stem Cell
- Progenitor
- Isolation (microbiology)
- Renal capsule
- Biology
- Cell biology
- Stem cell
- Good health and well-being