articleNew England Journal of MedicineMar 17, 2015BRONZE OA

Trial of Early, Goal-Directed Resuscitation for Septic Shock

PMPaul MounceyTMTiffany M. OsbornGSG. Sarah PowerDADavid A HarrisonZSZia Sadique

Chelsea and Westminster Hospital NHS Foundation Trust · Intensive Care National Audit & Research Centre · +8 more institutions

PubMed
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Abstract

Background

Early, goal-directed therapy (EGDT) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock. However, adoption has been limited, and uncertainty about its effectiveness remains.

Methods

We conducted a pragmatic randomized trial with an integrated cost-effectiveness analysis in 56 hospitals in England. Patients were randomly assigned to receive either EGDT (a 6-hour resuscitation protocol) or usual care. The primary clinical outcome was all-cause mortality at 90 days.

Citation impact

1,589
total citations
FWCI
160.61
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100%
References
31
Citations per year

Authors

14

Topics & keywords

Topics
Keywords
  • Medicine
  • Early goal-directed therapy
  • Resuscitation
  • Septic shock
  • Randomized controlled trial
  • Relative risk
  • Intensive care unit
  • Shock (circulatory)
UN Sustainable Development Goals
  • Good health and well-being
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