Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
University College Dublin · Nathan Kline Institute for Psychiatric Research · +5 more institutions
Abstract
Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-beta (Abeta)-containing brain extracts from humans with Alzheimer's disease or beta-amyloid precursor protein (APP) transgenic mice induced cerebral beta-amyloidosis and associated pathology in APP transgenic mice in a time- and concentration-dependent manner. The seeding activity of brain extracts was reduced or abolished by Abeta immunodepletion, protein denaturation, or by Abeta immunization of the host. The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent,…
Citation impact
- FWCI
- 13.36
- Percentile
- 100%
- References
- 31
Authors
18- MMMelanie Meyer‐LuehmannCorresponding
University College Dublin, Nathan Kline Institute for Psychiatric Research, Novartis (Switzerland), University of Basel, Hertie Institute for Clinical Brain Research, Novartis Institutes for BioMedical Research, University of Tübingen
- JCJanaky Coomaraswamy
University College Dublin, Nathan Kline Institute for Psychiatric Research, Novartis (Switzerland), University of Basel, Hertie Institute for Clinical Brain Research, Novartis Institutes for BioMedical Research, University of Tübingen
- TBTristan Bolmont
University College Dublin, Nathan Kline Institute for Psychiatric Research, Novartis (Switzerland), University of Basel, Hertie Institute for Clinical Brain Research, Novartis Institutes for BioMedical Research, University of Tübingen
- SAStephan A. Kaeser
University College Dublin, Nathan Kline Institute for Psychiatric Research, Novartis (Switzerland), University of Basel, Hertie Institute for Clinical Brain Research, Novartis Institutes for BioMedical Research, University of Tübingen
- CSClaudia Schaefer
University College Dublin, Nathan Kline Institute for Psychiatric Research, Novartis (Switzerland), University of Basel, Hertie Institute for Clinical Brain Research, Novartis Institutes for BioMedical Research, University of Tübingen
Topics & keywords
- Transgene
- Amyloid (mycology)
- Amyloidosis
- Genetically modified mouse
- In vivo
- Chemistry
- Amyloid precursor protein
- Phenotype