Microglia Development and Function
National Institutes of Health · National Institute of Neurological Disorders and Stroke · +1 more institution
Abstract
Proper development and function of the mammalian central nervous system (CNS) depend critically on the activity of parenchymal sentinels referred to as microglia. Although microglia were first described as ramified brain-resident phagocytes, research conducted over the past century has expanded considerably upon this narrow view and ascribed many functions to these dynamic CNS inhabitants. Microglia are now considered among the most versatile cells in the body, possessing the capacity to morphologically and functionally adapt to their ever-changing surroundings. Even in a resting state, the processes of microglia are highly dynamic and perpetually scan the CNS. Microglia are in fact vital participants in CNS…
Citation impact
- FWCI
- 30.02
- Percentile
- 100%
- References
- 224
Authors
3- DNDebasis NayakCorresponding
National Institutes of Health, National Institute of Neurological Disorders and Stroke
- TLTheodore L. Roth
National Institutes of Health, National Institute of Neurological Disorders and Stroke, University of Military Science and Technology
- DBDorian B. McGavern
National Institutes of Health, National Institute of Neurological Disorders and Stroke
Topics & keywords
- Microglia
- Neuroscience
- Biology
- Neurodegeneration
- Central nervous system
- Homeostasis
- Brain development
- Function (biology)