Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

Clarke, Robert; Peden, John F.; Hopewell, Jemma C.; Kyriakou, Theodosios; Goel, Anuj; Heath, Simon; Parish, Sarah; Barlera, Simona; Franzosi, Maria Grazia; Rust, Stephan; Bennett, Derrick; Silveira, Angela; Mälarstig, Anders; Green, Fiona R.; Lathrop, Mark; Gigante, Bruna; Leander, Karin; Fairé, Ulf dé; Seedorf, Udo; Hamsten, Anders; Collins, Rory; Watkins, Hugh; Farrall, Martin

doi:10.1056/nejmoa0902604

articleNew England Journal of MedicineDec 23, 2009BRONZE OA

Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

RCRobert Clarke JFJohn F. Peden JCJemma C. Hopewell TKTheodosios Kyriakou AGAnuj Goel

University of Oxford · Centre for Human Genetics · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Background

An increased level of Lp(a) lipoprotein has been identified as a risk factor for coronary artery disease that is highly heritable. The genetic determinants of the Lp(a) lipoprotein level and their relevance for the risk of coronary disease are incompletely understood.

Methods

We used a novel gene chip containing 48,742 single-nucleotide polymorphisms (SNPs) in 2100 candidate genes to test for associations in 3145 case subjects with coronary disease and 3352 control subjects. Replication was tested in three independent populations involving 4846 additional case subjects with coronary disease and 4594 control subjects.

Citation impact

1,631

total citations

FWCI: 65.14
Percentile: 100%
References: 40

Citations per year

Authors

23

Topics & keywords

Topics

Keywords

Lipoprotein(a)
Medicine
Coronary artery disease
Lipoprotein
Risk factor
Disease
Internal medicine
Genetic variants

UN Sustainable Development Goals

Good health and well-being

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