Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse
National University of Singapore · Shanghai Medical College of Fudan University · +1 more institution
Abstract
Hydrogen sulfide (H2S) is synthesized in the body from L-cysteine by several enzymes including cystathionine-gamma-lyase (CSE). To date, there is little information about the potential role of H2S in inflammation. We have now investigated the part played by H2S in endotoxin-induced inflammation in the mouse. E. coli lipopolysaccharide (LPS) administration produced a dose (10 and 20 mg/kg ip)- and time (6 and 24 h)-dependent increase in plasma H2S concentration. LPS (10 mg/kg ip, 6 h) increased plasma H2S concentration from 34.1 +/- 0.7 microM to 40.9 +/- 0.6 microM (n=6, P
Citation impact
- FWCI
- 19.95
- Percentile
- 100%
- References
- 33
Authors
10- LLLing LiCorresponding
National University of Singapore
- MBMadhav Bhatia
National University of Singapore
- YZYi Zhun Zhu
Shanghai Medical College of Fudan University, National University of Singapore
- YCYi Chun Zhu
Shanghai Medical College of Fudan University, National University of Singapore
- RRRaina Ramnath
National University of Singapore
Topics & keywords
- Cystathionine gamma-lyase
- Kidney
- Myeloperoxidase
- Chemistry
- Inflammation
- Lipopolysaccharide
- Proinflammatory cytokine
- Internal medicine