Five-Year Outcomes of a Randomized Phase III Trial Comparing Adjuvant Chemotherapy With S-1 Versus Surgery Alone in Stage II or III Gastric Cancer
Japanese Foundation For Cancer Research · Hyogo Medical University · +5 more institutions
Abstract
The overall survival rate at 5 years was 71.7% in the S-1 group and 61.1% in the surgery-only group (hazard ratio [HR], 0.669; 95% CI, 0.540 to 0.828). The relapse-free survival rate at 5 years was 65.4% in the S-1 group and 53.1% in the surgery-only group (HR, 0.653; 95% CI, 0.537 to 0.793). Subgroup analyses according to principal demographic factors such as sex, age, disease stage, and histologic type showed no interaction between treatment and any characteristic.
On the basis of 5-year follow-up data, postoperative adjuvant therapy with S-1 was confirmed to improve overall survival and relapse-free survival in patients with stage II or III gastric cancer who had undergone D2 gastrectomy.
Citation impact
- FWCI
- 52.94
- Percentile
- 100%
- References
- 29
Authors
10- MSMitsuru SasakoCorresponding
Japanese Foundation For Cancer Research
- SSShinichi Sakuramoto
Hyogo Medical University, Niigata Cancer Center Hospital, University of Tokyo Health Sciences, Taiho Pharmaceutical (Japan), National Cancer Center Hospital East, Japanese Foundation For Cancer Research, Kitasato University
- HKHitoshi Katai
Hyogo Medical University, Niigata Cancer Center Hospital, University of Tokyo Health Sciences, Taiho Pharmaceutical (Japan), National Cancer Center Hospital East, Japanese Foundation For Cancer Research, Kitasato University
- TKTaira Kinoshitá
Hyogo Medical University, Niigata Cancer Center Hospital, University of Tokyo Health Sciences, Taiho Pharmaceutical (Japan), National Cancer Center Hospital East, Japanese Foundation For Cancer Research, Kitasato University
- HFHiroshi Furukawa
Hyogo Medical University, Niigata Cancer Center Hospital, University of Tokyo Health Sciences, Taiho Pharmaceutical (Japan), National Cancer Center Hospital East, Japanese Foundation For Cancer Research, Kitasato University
Topics & keywords
- Medicine
- Hazard ratio
- Interim analysis
- Surgery
- Gastrectomy
- Clinical endpoint
- Cancer
- Stage (stratigraphy)
- Good health and well-being