Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures
Columbia University Irving Medical Center · Düsseldorf University Hospital · +2 more institutions
Abstract
BACKGROUND: The recent discovery of circulating endothelial progenitor cells (EPCs) has altered our understanding of new blood vessel growth such as occurs during collateral formation. Because diabetic complications occur in conditions in which EPC contributions have been demonstrated, EPC dysfunction may be important in their pathophysiology. METHODS AND RESULTS: EPCs were isolated from human type II diabetics (n=20) and age-matched control subjects (n=20). Proliferation of diabetic EPCs relative to control subjects was decreased by 48% (P
Citation impact
- FWCI
- 16.79
- Percentile
- 100%
- References
- 33
Authors
8- OMOren M. TepperCorresponding
Columbia University Irving Medical Center, Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, New York University
- RDRobert D. Galiano
Columbia University Irving Medical Center, Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, New York University
- JMJennifer M. Capla
Columbia University Irving Medical Center, Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, New York University
- CKChristoph Kalka
Columbia University Irving Medical Center, Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, New York University
- PJPaul J. Gagne
Columbia University Irving Medical Center, Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, New York University
Topics & keywords
- Medicine
- Progenitor cell
- Cell biology
- Adhesion
- Endothelial progenitor cell
- Progenitor
- Vascular disease
- Endothelial stem cell
- Good health and well-being