The Natural History of Chronic Allograft Nephropathy
Westmead Hospital · The University of Sydney
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Abstract
Background
With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure.
Methods
We evaluated the natural history of chronic allograft nephropathy in a prospective study of 120 recipients with type 1 diabetes, all but 1 of whom had received kidney-pancreas transplants. We obtained 961 kidney-transplant-biopsy specimens taken regularly from the time of transplantation to 10 years thereafter.
Results
Two distinctive phases of injury were evident as chronic allograft nephropathy evolved. An initial phase of early tubulointerstitial damage from ischemic injury (P
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1,933
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Authors
6Topics & keywords
Topics
Keywords
- Medicine
- Chronic allograft nephropathy
- Subclinical infection
- Immunosuppression
- Kidney disease
- Nephropathy
- Tacrolimus
- Transplantation
UN Sustainable Development Goals
- Good health and well-being
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