Structure of a V3-Containing HIV-1 gp120 Core
Scripps Research Institute · Los Alamos National Laboratory · +4 more institutions
Abstract
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
Citation impact
- FWCI
- 15.26
- Percentile
- 100%
- References
- 34
Authors
12- CHChih-chin HuangCorresponding
Scripps Research Institute, Los Alamos National Laboratory, Frederick National Laboratory for Cancer Research, National Institute of Allergy and Infectious Diseases, National Cancer Institute, Science Applications International Corporation (United States)
- MTMin Tang
Scripps Research Institute, Los Alamos National Laboratory, Frederick National Laboratory for Cancer Research, National Institute of Allergy and Infectious Diseases, National Cancer Institute, Science Applications International Corporation (United States)
- MZMei-Yun Zhang
Scripps Research Institute, Los Alamos National Laboratory, Frederick National Laboratory for Cancer Research, National Institute of Allergy and Infectious Diseases, National Cancer Institute, Science Applications International Corporation (United States)
- SMShahzad Majeed
Scripps Research Institute, Los Alamos National Laboratory, Frederick National Laboratory for Cancer Research, National Institute of Allergy and Infectious Diseases, National Cancer Institute, Science Applications International Corporation (United States)
- EMElizabeth Montabana
Scripps Research Institute, Los Alamos National Laboratory, Frederick National Laboratory for Cancer Research, National Institute of Allergy and Infectious Diseases, National Cancer Institute, Science Applications International Corporation (United States)
Topics & keywords
- V3 loop
- Context (archaeology)
- Immunodominance
- Glycoprotein
- Human immunodeficiency virus (HIV)
- Antibody
- Epitope
- Chemistry
- Good health and well-being