Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
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Abstract
Objective
Our aim was to test the association of vascular risk factor exposure in midlife with progression of MRI markers of brain aging and measures of cognitive decline.
Methods
A total of 1,352 participants without dementia from the prospective Framingham Offspring Cohort Study were examined. Multivariable linear and logistic regressions were implemented to study the association of midlife vascular risk factor exposure with longitudinal change in white matter hyperintensity volume (WMHV), total brain volume (TBV), temporal horn volume, logical memory delayed recall, visual reproductions delayed-recall (VR-d), and Trail-Making Test B-A (TrB-A) performance a decade later.
Citation impact
773
total citations
- FWCI
- 23.12
- Percentile
- 100%
- References
- 43
Citations per year
Authors
8Topics & keywords
Topics
Keywords
- Medicine
- Cognitive decline
- Internal medicine
- Risk factor
- Dementia
- Brain size
- Odds ratio
- Cardiology
UN Sustainable Development Goals
- Good health and well-being
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Funding
- SOSchool of Medicine, Boston UniversityAward: N01-HC-25195
- APAvanir Pharmaceuticals
- NINational Institutes of HealthAwards: AG031287, N01-HC-25195, AG08122
- NINational Institute on AgingAwards: R01 AG16495, N01-HC-25195, AG031287, AG08122, AG033193, AG16495
- NHNational Heart, Lung, and Blood InstituteAwards: AG08122, AG031287, N01-HC-25195, AG16495, AG033193
- NINational Institute on Deafness and Other Communication Disorders
- NINational Institute of Neurological Disorders and StrokeAwards: R01 NS17950, NS17950, N01-HC-25195