Central memory self/tumor-reactive CD8 + T cells confer superior antitumor immunity compared with effector memory T cells
National Institutes of Health · Howard Hughes Medical Institute · +2 more institutions
Abstract
Central memory CD8+ T cells (T(CM)) and effector memory CD8+ T cells (T(EM)) are found in humans and mice; however, their relative contributions to host immunity have only recently been examined in vivo. Further, the ability of T(CM) to treat an established tumor or infection has yet to be evaluated. To address the therapeutic potential of different tumor-reactive CD8+ T cell memory subsets, we used an established model for the in vitro generation of T(CM) and T(EM) by using IL-15 and IL-2, respectively. Adoptively transferred T(CM) exhibited a potent in vivo recall response when combined with tumor-antigen vaccination and exogenous IL-2, leading to the eradication of large established tumors. By contrast,…
Citation impact
- FWCI
- 10.67
- Percentile
- 100%
- References
- 26
Authors
12- CAChristopher A. KlebanoffCorresponding
National Institutes of Health, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Cancer Institute
- LGLuca Gattinoni
National Institutes of Health, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Cancer Institute
- PTParizad Torabi‐Parizi
National Institutes of Health, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Cancer Institute
- KKKeith Kerstann
National Institutes of Health, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Cancer Institute
- ARAdela R. Cardones
National Institutes of Health, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Cancer Institute
Topics & keywords
- Cytotoxic T cell
- CD8
- Adoptive cell transfer
- Biology
- Homing (biology)
- In vivo
- Immunology
- T cell
- Good health and well-being