BRAF Mutations in Hairy-Cell Leukemia
University of Perugia · Azienda Ospedaliera di Perugia · +17 more institutions
Abstract
Hairy-cell leukemia (HCL) is a well-defined clinicopathological entity whose underlying genetic lesion is still obscure.
We searched for HCL-associated mutations by performing massively parallel sequencing of the whole exome of leukemic and matched normal cells purified from the peripheral blood of an index patient with HCL. Findings were validated by Sanger sequencing in 47 additional patients with HCL.
Citation impact
- FWCI
- 50.95
- Percentile
- 100%
- References
- 44
Authors
36- ETEnrico TiacciCorresponding
University of Perugia
- ВТВладимир Трифонов
Azienda Ospedaliera di Perugia, Columbia University, Ospedale Santa Maria, University of Perugia
- GSGianluca Schiavoni
University of Padua, University of Perugia, Ospedale Santa Maria, Azienda Ospedaliera di Perugia
- ABAntony B. Holmes
Columbia University, University of Perugia, Ospedale Santa Maria, Azienda Ospedaliera di Perugia
- WKWolfgang Kern
University of Perugia, Ospedale Santa Maria, Azienda Ospedaliera di Perugia, Munich Leukemia Laboratory (Germany)
Topics & keywords
- Sanger sequencing
- Hairy cell leukemia
- Cancer research
- Medicine
- Mutation
- Missense mutation
- Exome
- MAPK/ERK pathway