Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia
John Radcliffe Hospital · University of Oxford · +2 more institutions
Abstract
Antibodies that immunoprecipitate (125)I-alpha-dendrotoxin-labelled voltage-gated potassium channels extracted from mammalian brain tissue have been identified in patients with neuromyotonia, Morvan's syndrome, limbic encephalitis and a few cases of adult-onset epilepsy. These conditions often improve following immunomodulatory therapies. However, the proportions of the different syndromes, the numbers with associated tumours and the relationships with potassium channel subunit antibody specificities have been unclear. We documented the clinical phenotype and tumour associations in 96 potassium channel antibody positive patients (titres >400 pM). Five had thymomas and one had an endometrial adenocarcinoma. To…
Citation impact
- FWCI
- 46.02
- Percentile
- 100%
- References
- 44
Authors
10- SRSarosh R. IraniCorresponding
John Radcliffe Hospital, University of Oxford
- SKSian K Alexander
University of Oxford, John Radcliffe Hospital
- PWPatrick Waters
John Radcliffe Hospital, University of Oxford
- KAKleopas A. Kleopa
Cyprus Institute of Neurology and Genetics
- PPPhilippa Pettingill
John Radcliffe Hospital, University of Oxford
Topics & keywords
- Limbic encephalitis
- Neuromyotonia
- Antibody
- Potassium channel
- Protein subunit
- Encephalitis
- Biology
- Pathology
- Good health and well-being
Funding
- DFDana Foundation
- WTWellcome Trust
- NINational Institute for Health and Care Research
- EREpilepsy Research UK
- RPResearch Promotion Foundation
- UOUniversity of Crete
- NINational Institutes of HealthAwards: U24NS050606, IA 52242
- DFDirectorate for Biological Sciences
- UOUniversity of California, Davis
- NINational Institute of Mental Health
- NINational Institute of Neurological Disorders and Stroke