Reliable B Cell Epitope Predictions: Impacts of Method Development and Improved Benchmarking
Technical University of Denmark · National University of General San Martín
Abstract
The interaction between antibodies and antigens is one of the most important immune system mechanisms for clearing infectious organisms from the host. Antibodies bind to antigens at sites referred to as B-cell epitopes. Identification of the exact location of B-cell epitopes is essential in several biomedical applications such as; rational vaccine design, development of disease diagnostics and immunotherapeutics. However, experimental mapping of epitopes is resource intensive making in silico methods an appealing complementary approach. To date, the reported performance of methods for in silico mapping of B-cell epitopes has been moderate. Several issues regarding the evaluation data sets may however have led…
Citation impact
- FWCI
- 8.87
- Percentile
- 100%
- References
- 34
Authors
4Topics & keywords
- Epitope
- In silico
- Benchmark (surveying)
- Context (archaeology)
- Computer science
- Computational biology
- Benchmarking
- Antigen