EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
Brigham and Women's Hospital · University of Michigan · +1 more institution
Abstract
The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to aggressive prostate cancer. Here we investigate the functional role of EZH2 in cancer cell invasion and breast cancer progression. EZH2 transcript and protein were consistently elevated in invasive breast carcinoma compared with normal breast epithelia. Tissue microarray analysis, which included 917 samples from 280 patients, demonstrated that EZH2 protein levels were strongly associated with breast cancer aggressiveness. Overexpression of EZH2 in immortalized human mammary epithelial cell lines promotes anchorage-independent growth and cell invasion. EZH2-mediated cell invasion…
Citation impact
- FWCI
- 12.83
- Percentile
- 100%
- References
- 38
Authors
15- CGCelina G. KleerCorresponding
Brigham and Women's Hospital, University of Michigan, University of Amsterdam
- QCQi Cao
Brigham and Women's Hospital, University of Michigan, University of Amsterdam
- SVSooryanarayana Varambally
Brigham and Women's Hospital, University of Michigan, University of Amsterdam
- RSRonglai Shen
Brigham and Women's Hospital, University of Michigan, University of Amsterdam
- IOIchiro Ota
Brigham and Women's Hospital, University of Michigan, University of Amsterdam
Topics & keywords
- Cancer research
- Breast cancer
- Biology
- EZH2
- Neoplastic transformation
- Repressor
- Cancer
- Malignant transformation
- Good health and well-being