articleAngewandte Chemie International EditionJul 7, 2008Closed access

A Reducing and Oxidizing System Minimizes Photobleaching and Blinking of Fluorescent Dyes

JVJan VogelsangRKRobert KasperCSChristian SteinhauerBPBritta PersonMHMike Heilemann

Center for NanoScience · Bielefeld University

PubMed
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Abstract

On the ROXS: Photobleaching represents one of the main limitations of modern fluorescence microscopy. A reducing and oxidizing system (ROXS) has been introduced that recovers triplet states as well as charge-separated states through electron-transfer reactions (see picture). Thus the blinking and photobleaching of fluorophores is strikingly reduced.

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Topics & keywords

Topics
Keywords
  • Photobleaching
  • Oxidizing agent
  • Photochemistry
  • Fluorescence
  • Chemistry
  • Charge (physics)
  • Electron transfer
  • Nanotechnology
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