Dynamics of the Immune Reaction to Pancreatic Cancer from Inception to Invasion
Cancer Research Institute of the Slovak Academy of Sciences · Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · +4 more institutions
Abstract
The dynamics of cancer immunosurveillance remain incompletely understood, hampering efforts to develop immunotherapy of cancer. We evaluated the evolving in vivo immune response to a spontaneous tumor in a genetically defined mouse model of pancreatic ductal adenocarcinoma from the inception of preinvasive disease to invasive cancer. We observed a prominent leukocytic infiltration even around the lowest grade preinvasive lesions, but immunosuppressive cells, including tumor-associated macrophages, myeloid-derived suppressor cells (MDSC), and regulatory T cells (Treg), dominated the early response and persisted through invasive cancer. Effector T cells, however, were scarce in preinvasive lesions, found in only…
Citation impact
- FWCI
- 3.23
- Percentile
- 100%
- References
- 58
Authors
6- CECarolyn E. ClarkCorresponding
Cancer Research Institute of the Slovak Academy of Sciences
- SRSunil R. Hingorani
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, University of Washington, Fred Hutch Cancer Center, Cancer Research Center
- RMRosemarie Mick
University of Pennsylvania
- CCChelsea Combs
Cancer Research Institute of the Slovak Academy of Sciences
- DADavid A. Tuveson
Cancer Research Institute of the Slovak Academy of Sciences
Topics & keywords
- Immunosurveillance
- Immune system
- Pancreatic cancer
- Immunotherapy
- Cancer
- Cancer research
- Immunology
- Cancer immunotherapy
- Reduced inequalities