BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions
University of Cambridge · Wellcome/MRC Institute of Metabolic Science · +11 more institutions
Abstract
Thermogenesis in brown adipose tissue (BAT) is fundamental to energy balance and is also relevant for humans. Bone morphogenetic proteins (BMPs) regulate adipogenesis, and, here, we describe a role for BMP8B in the direct regulation of thermogenesis. BMP8B is induced by nutritional and thermogenic factors in mature BAT, increasing the response to noradrenaline through enhanced p38MAPK/CREB signaling and increased lipase activity. Bmp8b(-/-) mice exhibit impaired thermogenesis and reduced metabolic rate, causing weight gain despite hypophagia. BMP8B is also expressed in the hypothalamus, and Bmp8b(-/-) mice display altered neuropeptide levels and reduced phosphorylation of AMP-activated protein kinase (AMPK),…
Citation impact
- FWCI
- 29.36
- Percentile
- 100%
- References
- 62
Authors
17- AJAndrew J. WhittleCorresponding
University of Cambridge, Wellcome/MRC Institute of Metabolic Science, Addenbrooke's Hospital, MRC Epidemiology Unit
- SCStefania Carobbio
University of Cambridge, Addenbrooke's Hospital
- LMLuís Martins
Universidade de Santiago de Compostela, Centro de Investigación Biomédica en Red, Instituto de Investigación Sanitaria de Santiago
- MSMarc Slawik
University of Cambridge, LMU Klinikum, Addenbrooke's Hospital
- EHElayne Hondares
Centro de Investigación Biomédica en Red, Universitat de Barcelona
Topics & keywords
- Thermogenesis
- Biology
- AMPK
- Endocrinology
- Internal medicine
- Brown adipose tissue
- Protein kinase A
- AMP-activated protein kinase