Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication
National Institute of Allergy and Infectious Diseases · National Cancer Institute · +2 more institutions
Abstract
Antibodies against nuclear self-antigens are characteristic of systemic autoimmunity, although mechanisms promoting their generation and selection are unclear. Here, we report that B cells containing the Y-linked autoimmune accelerator (Yaa) locus are intrinsically biased toward nucleolar antigens because of increased expression of TLR7, a single-stranded RNA-binding innate immune receptor. The TLR7 gene is duplicated in Yaa mice because of a 4-Megabase expansion of the pseudoautosomal region. These results reveal high divergence in mouse Y chromosomes and represent a good example of gene copy number qualitatively altering a polygenic disease manifestation.
Citation impact
- FWCI
- 23.17
- Percentile
- 100%
- References
- 23
Authors
6- PPPrapaporn Pisitkun
National Institute of Allergy and Infectious Diseases, National Cancer Institute, Center for Cancer Research, The University of Texas Southwestern Medical Center
- JAJonathan A. Deane
National Institute of Allergy and Infectious Diseases, National Cancer Institute, Center for Cancer Research, The University of Texas Southwestern Medical Center
- MJMichael J. Difilippantonio
National Institute of Allergy and Infectious Diseases, National Cancer Institute, Center for Cancer Research, The University of Texas Southwestern Medical Center
- ТНТ. Н. Тарасенко
National Institute of Allergy and Infectious Diseases, National Cancer Institute, Center for Cancer Research, The University of Texas Southwestern Medical Center
- ABAnne B. Satterthwaite
National Institute of Allergy and Infectious Diseases, National Cancer Institute, Center for Cancer Research, The University of Texas Southwestern Medical Center
Topics & keywords
- TLR7
- Biology
- Gene
- Autoimmunity
- Locus (genetics)
- Gene duplication
- Antigen
- RNA
- Good health and well-being