Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression
Louisiana State University Health Sciences Center New Orleans · Brigham and Women's Hospital · +1 more institution
Abstract
Ischemic stroke triggers lipid peroxidation and neuronal injury. Docosahexaenoic acid released from membrane phospholipids during brain ischemia is a major source of lipid peroxides. Leukocyte infiltration and pro-inflammatory gene expression also contribute to stroke damage. In this study using lipidomic analysis, we have identified stereospecific messengers from docosahexaenoate-oxygenation pathways in a mouse stroke model. Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins. The newly discovered brain messenger 10,17S-docosatriene potently inhibited leukocyte infiltration, NFκB, and cyclooxygenase-2 induction in experimental stroke and…
Citation impact
- FWCI
- 28.17
- Percentile
- 100%
- References
- 37
Authors
11- VLVictor L. Marcheselli
Louisiana State University Health Sciences Center New Orleans
- SHSong Hong
Brigham and Women's Hospital, Harvard University
- WJWalter J. Lukiw
Louisiana State University Health Sciences Center New Orleans
- XHXiao Hua Tian
Louisiana State University Health Sciences Center New Orleans
- KGKarsten Gronert
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Neuroprotection
- Docosahexaenoic acid
- Lipid signaling
- Pharmacology
- Lipid peroxidation
- Second messenger system
- Arachidonic acid
- Ischemia
- Good health and well-being