reviewLearning & MemoryApr 20, 2009DIAMOND OA

Extinction circuits for fear and addiction overlap in prefrontal cortex

JPJamie PetersPWPeter W. KalivasGJGregory J. Quirk

University of Puerto Rico System · Medical University of South Carolina

PubMed
Indexed incrossrefpubmed

Abstract

Extinction is a form of inhibitory learning that suppresses a previously conditioned response. Both fear and drug seeking are conditioned responses that can lead to maladaptive behavior when expressed inappropriately, manifesting as anxiety disorders and addiction, respectively. Recent evidence indicates that the medial prefrontal cortex (mPFC) is critical for the extinction of both fear and drug-seeking behaviors. Moreover, a dorsal-ventral distinction is apparent within the mPFC, such that the prelimbic (PL-mPFC) cortex drives the expression of fear and drug seeking, whereas the infralimbic (IL-mPFC) cortex suppresses these behaviors after extinction. For conditioned fear, the dorsal-ventral dichotomy is…

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3

Topics & keywords

Topics
Keywords
  • Extinction (optical mineralogy)
  • Prefrontal cortex
  • Neuroscience
  • Infralimbic cortex
  • Psychology
  • Nucleus accumbens
  • Amygdala
  • Addiction
UN Sustainable Development Goals
  • Good health and well-being
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